The Sanctic Conclave serves as a swift reaction unit, commanded by a Grand Master piloting a Nemesis Dreadknight equipped with an upgraded frame featuring Nemesis Flail and Sublimator weapon choices.

He is supported by five Brotherhood Terminators, five Paladins, and a 20-member force of Grey Knights, which can be assembled into Strike, Interceptor, Purifier, or Purgation Squads.